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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC50 value (IC50=1 M), and high cell membrane permeability (Table 5), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors

No prior weight-loss pharmacotherapy has approached this magnitude in a registration-grade study

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Simplified Questionnaires for PN Diagnosis As a solution, a 5-item patient-led questionnaire (Fig