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Description

Tregs have increased transcript levels of the amino acid sensors Sestrin1, CASTOR1, CASTOR2 as well as components of the GATOR1 and GATOR2 complexes

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Studies suggest that the VEGF/VEGFR-2 pathway may be particularly relevant, as its activation seems to trigger intracellular signaling cascades that potentially influence endothelial cell migration, proliferation, and survival

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In inflamed IBD gut, their metabolic reprogramming is characterized by significant downregulation of the anti-inflammatory nuclear receptor PPAR and FAO pathways (204)

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