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Therefore, it is urgent to find and explore new therapeutic drugs and targets for lung cancer [9, 10]

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Acta Pharmacol Sin 44:22302242 Kolbrink B, von Samson-Himmelstjerna FA, Messtorff ML, Riebeling T, Nische R, Schmitz J, Brsen JH, Kunzendorf U, Krautwald S (2022) Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury

Amary et al., 2011), leading to a hypermethylation phenotype and may alter the differentiation of cancer stem cells (Yang et al., 2012

By using ERK/MAPK activator (TPA) and ferroptosis activator (Era), we show that when combined with TPA, the inhibition of SS on the proliferation, migration, and invasion of BC cells could partially be neutralized, indicating that the ERK2/MAPK signaling pathway may be involved in the ability of SS to regulate BC cells