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A prospective study of duodenal bulb biopsy in newly diagnosed and established adult celiac disease

The subgroup analysis based on PWV measurement site (Figure 4) showed that L-citrulline supplementation significantly improved BA-PWV in middle-aged and elderly individuals (WMD = 1.11, 95% CI: 1.37 to 0.85, p 0.1)

Despite this early result suggesting a lifespan benefit similar to CR, subsequent studies have indicated that the enhancement in life expectancy promoted by IF, if present, is certainly less robust [9, 10]

Given the central role of folate in one-carbon metabolism, optimizing folate status in TT carriers could enhance epigenetic stability, particularly in tissues sensitive to methylation imbalance (174)

For example, calcium, magnesium, zinc and iron are all absorbed via the same pathways