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The Yeast Cadmium Factor 1 (Ycf1) performs such a protective function by transporting the tripeptide glutathione, the main non-protein thiol in cells, upon oxidation to maintain redox balance or after conjugation to toxic heavy metals such as cadmium, mercury, or lead into vacuoles 1,2,3,4,5

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Furthermore, inorganic arsenic (As 3+ and As 5+ ), which can be found at elevated levels in drinking water in certain regions, has been shown to correlate with increased bladder cancer risk due to chronic consumption (Wong et al., 2024)

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