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A decrease in Prx2 linkage to the RBC membrane with OS conditions was also observed in beta-thalassemic mice RBCs, probably due to the increase in metHb that binds to the membrane, reducing the access of Prx2 to the same site [99]

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[7] The synthesis of GSH occurs exclusively in the cytosol, from where it is transported to different subcellular compartments, such as the endoplasmic reticulum (ER), Golgi apparatus, mitochondria and the nuclear matrix