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There is no published RCT and no long-term human safety data

Drug Interactions Neomycin, colchicine, para-aminosalicylic acid, or excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12

[2] [7] Treatment response should be monitored through clinical improvement, reticulocyte count (which typically rises within a week), and full blood count after 8 weeks

PMCID: PMC5215694

13,14 Other medications commonly associated with ED include antihypertensive agents such as calcium channel blockers, beta-blockers, and thiazide diuretics as well as miscellaneous agents including methotrexate, interferon-alpha, and 5-alpha reductase inhibitors