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Oxidized GSH (GSSG) is reduced back to GSH by GSR in an NADPH-dependent manner, thereby sustaining cellular antioxidant defense and linking redox buffering to central metabolic pathways that generate NADPH, such as the PPP and IDH-dependent reactions

Abbreviations GSH: l-glutathione ATP: adenosine triphosphoric acid -GCS: -glutamylcysteine synthetase GS: glutathione synthetase GGT: -glutamyltranspeptidase PepT: tripeptidase CD: cysteine desulfhydrase CBL: -lyase GBE: glycogen-branching enzyme l-SDs: l-serine deaminases PK: pyruvate kinase PEP: phosphoenolpyruvic acid G6P: glucose 6-phosphate F6P: fructose 6-phosphate PFK: phosphofructose kinase IPTG: isopropyl -D-1-thiogalactopyranoside DCW: dry cell weight 2-DE: two-dimensional electrophoresis TCA: trichloroacetic acid CBB: coomassie brilliant blue EMP: embden meyerhof pathway References Meister A, Anderson ME

doi: 10.1016/j.neuron.2011.09.011