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David Perlmutter, MD Hope Center for Neurological Disorders Washington University in St. Louis Parkinson's disease has increased at a pace that genetics alone cannot explain., As @raydorseymd explains, only a minority of cases are linked to known genetic risk factors. For the vast majority of Parkinson's disease linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons ScienceDirect The Empowering Neurologist Dr. David Perlmutter and Dr. Matt Phillips Molecular mechanisms of exercise induced neuroprotection against Parkinson's disease ScienceDirect

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