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As illustrated in Figure 2 , this reprogramming shifts cells from their normal metabolic states toward maladaptive profiles that support viral persistence rather than effective immunity

Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme

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The net result is improving cellular energy state (Greenhaff et al., 1993), facilitating intracellular energy transport (Saks et al., 1978), improving the efficiency of cellular energy utilization (van Leemputte et al., 1999), and stimulating mitochondrial respiration (Kay et al., 2000)