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6 Targeting ROS or mitochondria in RA therapy drugs 6.1 Inhibition of inflammation Inhibition of inflammatory response is critical in the course of RA treatment, and biological agents, such as TNF- monoclonal antibodies, IL-6 monoclonal antibodies, and JAK pathway inhibitors, have been developed for inflammatory factors and have achieved significant clinical efficacy

selenium is a component of the antioxidant enzyme glutathione peroxidase, which helps to fight cell-damaging free-radicals

Cox TC, Bawden MJ, Martin A, May BK (1991) Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA

As we get older, it gets difficult to do this, but with the help of peptide therapy, we can improve results

This process generates lipid peroxides as well as other active complexes propagating and repeating spontaneously and oxidize nearby molecules