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However, genetic loss of the rate-limiting enzyme, carnitine palmitoyl-transferase 1A (Cpt1A), a protein found in the outer mitochondrial membrane, did not reduce Treg cell numbers or function in vitro or in vivo (100)

Janczy A, Aleksandrowicz-Wrona E, Kochan Z, Magorzewicz S (2020) Impact of diet and synbiotics on selected gut bacteria and intestinal permeability in individuals with excess body weight a prospective, randomized study

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

Arch Intern Med 170(3):256261

doi:10.1007/s11154-016-9384-x 63