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Patients with Normal Intestinal Absorption Where the oral route is not deemed adequate, initial treatment similar to that for patients with pernicious anemia may be indicated depending on the severity of the deficiency

Advances in enteric coating, nanoparticle encapsulation, and peptide stapling are opening pathways to oral bioavailability a potential game-changer for therapeutic applications

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The relatively rapid onset of action supports peripheral desensitisation through modulating pain mediators or deactivating iron channels at the nerve ending as potential pain relief mechanisms