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In reaction to Nrf2 activators, AKR1C1 and AKR1C2 are continuously excessively expressed and detoxify by decreasing 4-HNE (Penning 2017)

It appears that when breast cancer cells want to mediate brain metastasis, they create an immunosuppressive TME

Researchers have found that the diversity and species of bacteria in the kidneys plays a significant role in the formation of kidney stones from oxalate.[ref] Joint pain, eye problems, skin deposition In addition to forming kidney stones, oxalate crystals can sometimes be deposited in the joints, skin, and retina

L.SoerjomataramI.et al (2024)

Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials