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-GT is located at luminal endothelial cell membranes of these organs with its active site on the extracellular surface of the membrane rightly positioned for the cleavage of GSH from the blood circulation (Fig

We speculate that this specific residue, which is located in the linker region of human parkins sequence, could play a key role in its folding, in interactions with other molecules, and thus in its functions, akin to the phosphorylation at serine 65 during toxin-induced mitophagy in mammalian cells [3, 30, 34]

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