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The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways

Sato Y, Atarashi K, Plichta DR, Arai Y, Sasajima S, Kearney SM, Suda W, Takeshita K, Sasaki T, Okamoto S, et al

Nevertheless, the preclinical animal model gives proof-of-concept and is pivotal for designing clinical trials and successfully generating a wealth of data in drug discovery