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These mechanisms of action encompass both direct interventions on cancer cells and indirect modulation of the tumor microenvironment, potentially leading to apoptosis, autophagy, or necroptosis

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Furthermore, although CsA is a well-known inhibitor of the mitochondrial permeability transition pore through blocking cyclophilin D [54], examination of its immediate effects on mitochondrial function showed only marginal changes (Additional file 1: Fig