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[42] [43] Half-life is determined by clearance (CL) and volume of distribution (V D ) and the relationship is described by the following equation: In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed

Maintenance Dose: Once levels improve, the frequency decreases

Many patients find that avoiding alcohol entirely during their 12-16 week treatment produces noticeably better results

In fact, increased energy is one of the most promised benefits of B12

However, it is important to be aware of the molecules safety profile and potential side effects before administering it to test subjects