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DoD requires a program objective memorandum (POM) commitment to be secured, preferably during the Phase II award period of performance

Scientists understand that newly implanted regenerative stem cells require vast amounts of SAM-e (driven by B12) to successfully generate new myelin sheaths and repair the nervous system

10.1038/s41586-019-1705-2 12 BogdanA

For maximum effect , some researchers combine the two under proper protocols

In the Wnt/-catenin pathway, lipoprotein receptor-related protein (LRP) and frizzled (FZD) act as Wnt receptors and form a complex with Wnt proteins to activate downstream signaling