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Tesofensine offers a central nervous system approach, suppressing appetite while simultaneously increasing resting energy expenditure through triple monoamine reuptake inhibition

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15) with water-soluble groups (-OH, -COOH, -SO 3 Na) or 39d and 39e (Fig

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Parent precursor masses of 124.0, 399.3, 385.1, and 665.1 Da and Q3 masses set to m/z 80.0, 250.1, 136.0, and 136.0 were used for the quantitation of NA, SAM, SAH, and NAD+, respectively