chac1 glutathione Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Identification of Juglone, a 'first-in-class'

Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv Frontiers CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers Regulation of ChaC1. Oxidative and ER stress, and viral infection Download Scientific Diagram Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation Cell Death & Disease The CHAC1 inhibited Notch3 pathway is involved in temozolomide induced glioma cytotoxicity ScienceDirect

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