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The approval of XPOVIO was based upon the efficacy and safety in a prespecified subgroup analysis of the 83 patients whose disease was refractory to bortezomib, carfilzomib, lenalidomide, pomalidomide, and daratumumab, as the benefit-risk ratio appeared to be greater in this more heavily pretreated population than in the overall trial population

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Chloroquine (CQ), which is commonly employed in the management of malaria and inflammatory conditions, has demonstrated potential as a novel anticancer agent through its ability to inhibit autophagy and induce apoptosis 10