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Therefore, solely optimizing delivery or targeting may be insufficient to fully resolve off-target toxicity and variability in therapeutic outcomes

SI administration markedly enhances GPX, GSH, CAT, and SOD activities while reducing MDA levels, thereby alleviating oxidative stress

Overall, this work provided a cascade-enhanced nanocatalytic strategy against hypoxic tumor by integrating respiration inhibition, GSH depletion and targeted delivery for effective starving-chemodynamic therapy