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Pharmacological targeting of endoplasmic reticulum stress in disease

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While our mechanistic data and mouse model results are compelling, a formal statistical causal inference or randomized controlled design would be required to definitively attribute hyperprogression to the immunotherapy regimen

Kleinecke S, Richert S, de Hoz L, Brugger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Luchtenborg C, Mobius W, Willison H, Baes M, Nave KA, Kassmann CM (2017) Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy