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Considering that RGMa has a potential to induce cleaved caspase 3-mediated cell death in immature neurons 31 , RGMa upregulation likely impairs the survival of DCX-positive immature neurons, leading to a reduction in their number under diabetic condition

and the removal is reported with 61892

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But there are also studies that did not find or doubt this difference

SAM is an essential cofactor in the pathway of synthesis of epinephrine, which is involved in learning processes and memory consolidation [29, 30]