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The wound healing and repair process involves a finely tuned balance of haemostasis, inflammation, proliferation, and remodelling, but in diabetes, chronic non-healing ulcers are caused by a lengthening of an inflammatory response time, high production of reactive oxygen species (ROS), and immune dysfunction

doi: 10.1016/0039-128x(94)90006-x 74 RyanR

R.UmbarkarP.GautamR.et al (2021)

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Since starting a medication to lower uric acid levels can also trigger a gout attack, your doctor will likely also prescribe another medication, usually an NSAID or colchicine, to take daily for the first few months to help prevent further gout attacks while your body adjusts to taking a uric acid lowering medication