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However, other MC4R-selective agonists demonstrated no pressor effects in the clinic (48, 57, 60, 62, 82, 101)

One point of controversy that has been discussed since the seminal Framingham paper is that in the Framingham cohort up to 35% of CHD incidence occurred in subjects with a total cholesterol level of less than 5.2mmol/L ( 3mmol/L (116mg/dL), which is a sufficient exposure over the course of a 20-40 year period to contribute to atherosclerosis (discussed in LDL section below)

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doi: 10.1016/j.gene.2020.144635 46 HuangGQuanLLiQZhouXHanMPengFet al

Resveratrol attenuates Trimethylamine-N-Oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota