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Specifically, the only RCT aiming to investigate the BW lowering efficacy of mazdutide in patients without T2D was limited to Chinese patients and referred to different cut offs for the definition of obesity (BMI 28 kg/m 2 ) 49

What may improve includes: Pain intensity and frequency Radiating symptoms (sciatica) Morning stiffness and mobility Tolerance for sitting, standing, and daily activities Sleep quality affected by pain Dependence on pain medications Many users with disc herniations report 50% to 80% improvement in symptoms while their imaging findings remain unchanged

Together they produce the kind of tissue repair outcomes that neither manages independently, and that standard anti-inflammatory approaches cannot replicate

& Rudensky, A