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[DOI] [PubMed] [Google Scholar] 18.Zhu Z., Cao F., Li X

1 Even in darkness, the retina consumes large amounts of oxygen-often more than it does in light-making it particularly vulnerable to oxidative damage

Clinically, Epi_2 tumors are associated with lymph-node metastasis and refractoriness to both immune-checkpoint blockade and anti-EGFR therapies (54), implying that therapeutic targeting of cuproptosis escape mechanisms could reverse such resistance