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The discovery of GPCRs constitutive activity has had a profound impact both in the pharmacological study of these receptors and in an increased understanding of the molecular mechanisms of certain diseases with which it is associated

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Exposure to the drug is quantified by the area under the plasma concentration-time curve (AUC) which is directly proportional to the total amount of unchanged drug that reaches the systemic circulation

DOI:10.1093/embo-reports/kve046 71

Disseminated disease has been described in 936% of kidney recipients, 1520% of lung recipients, 2035% of heart recipients and 5060% of liver recipients with IA 28