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The similarities are restricted while differences are considerable

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An extremely inflammatory type of programmed cell death in reaction to infectious stimuli, pyroptosis, is triggered by NLRP3-induced caspase-1 activation, which in turn triggers the production of pro-inflammatory cytokines

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Indeed, although both proteins impair plasma TG clearance when bound to TRLs, their impact on HDL functionality is opposite: apoC3 exerts a negative effect and apoC1 a positive effect on the atheroprotective functions of HDL, including its inhibitory effect on CETP (see Table 1)

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