l-carnitine effect on hypothyroidism Frontiers l carnitine hashimoto's thyroiditis 2

MRI, magnetic resonance imaging

doi: 10.1136/adc.74.6.475 18 WangZ

Kings Computational Research, Engineering and Technology Environment (CREATE)

The modification is widely involved in cell metabolism, proliferation, differentiation, and apoptosis by affecting protein stability, activity, subcellular localization, and protein interaction (Jiang et al., 2023)

Furthermore, given the aforementioned purported mechanisms for the improving effects of L-carnitine/synbiotics on weight or metabolic parameters, it could be conceived that concomitant supplementation of L-carnitine and synbiotics may confer more pronounced impacts on these indicators, potentially through simultaneous modulation of energy homeostasis (8, 30), increasing fatty acid oxidation (8, 30), reducing adipogenesis or stimulating adipocyte lipolysis (21, 30), alleviating insulin resistance and glucose homeostasis (10, 31, 33), or attenuating systemic inflammation (56, 57), in a complementary or synergistic manner probably mediated through concurrent targeting of metabolic/inflammatory signaling pathways including CPT-Ia (20, 21), PDHC (8, 19), PPAR- (21, 31, 37), AMPK (30, 37), or NF-B (31, 34)