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For instance, aspirin decreased pyloric sphincter pressure (23), while indomethacin was variously shown to have increased lower esophageal sphincter (18, 20, 22), decreased (19, 21) or had no effect (23) on lower esophageal sphincter pressure

While those studies measured endogenous GLP-1 in blood samples rather than pharmaceutical preparations, the principle holds: peptides and temperature are not friends