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Using standardized tools like the Naranjo scale or WHO-UMC criteria , clinical teams classify AEs as related, unrelated, or indeterminate

Supplementary material The Supplementary Material for this article can be found online at: Glossary 5-HT 5-Hydroxytryptamine (Serotonin) 8-OHdG 8-Hydroxy-2-deoxyguanosine AGE Advanced Glycation End products ARE Antioxidant Response Element ASC Apoptosis-associated Speck-like protein containing a CARD ASK1 Apoptosis Signal-regulating Kinase 1 BDNF Brain-Derived Neurotrophic Factor CAP Capsaicin (in context of TRPV1 currents) CCL2 C-C Motif Chemokine Ligand 2 CCR2 C-C Chemokine Receptor Type 2 CD68 Cluster of Differentiation 68 CMAP Compound Muscle Action Potential CRMP2 Collapsin Response Mediator Protein 2 CS/-GP Chitosan/-Glycerophosphate CX3CL1 Chemokine (C-X3-C motif) ligand 1 CX3CR1 Chemokine (C-X3-C motif) receptor 1 CYP2D6 Cytochrome P450 2D6 CYP3A4 Cytochrome P450 3A4 DMTs Disease-Modifying Therapies DPN Diabetic Peripheral Neuropathy DRG Dorsal Root Ganglion ErbB2 Erb-B2 Receptor Tyrosine Kinase 2 FREMS Frequency Rhythmic Electrical Modulated System GDNF Glial cell line-Derived Neurotrophic Factor GFAP Glial Fibrillary Acidic Protein HbA1c Hemoglobin A1c HDAC Histone Deacetylase HDAC1 Histone Deacetylase 1 HDAC4 Histone Deacetylase 4 HDAC6 Histone Deacetylase 6 HF High Frequency (in HRV context) HIF-1 Hypoxia-Inducible Factor 1-alpha HO-1 Heme Oxygenase-1 HRV Heart Rate Variability HVA High-Voltage-Activated (calcium channels) ICAM-1 Intercellular Adhesion Molecule 1 IDF International Diabetes Federation IENFD Intraepidermal Nerve Fiber Density IB Inhibitor of kappa B IKK IB kinase beta IL-1 Interleukin-1 beta IL-18 Interleukin-18 IL-6 Interleukin-6 IRAK1 Interleukin-1 Receptor-Associated Kinase 1 JNK c-Jun N-terminal kinase LD50 Median Lethal Dose LPH Lactase phlorizin hydrolase MBP Myelin Basic Protein MCP-1 Monocyte Chemoattractant Protein-1 miR-128 microRNA-128 miR-146a microRNA-146a miR-30 microRNA-30 miRNAs microRNAs MMP-9 Matrix Metalloproteinase-9 MnSOD Manganese Superoxide Dismutase mtDNA Mitochondrial DNA Nav1.7 Voltage-gated sodium channel 1.7 Nav1.8 Voltage-gated sodium channel 1.8 NE Norepinephrine NF-B Nuclear Factor kappa-B NGF Nerve Growth Factor NLRP3 NLR Family Pyrin Domain Containing 3 NOX2 NADPH Oxidase 2 Nrf2 Nuclear factor erythroid 2-related factor 2 p38MAPK p38 Mitogen-Activated Protein Kinase PAF Platelet-Activating Factor PF Paeoniflorin PKC Protein Kinase C PLGA-PEG Poly(lactic-co-glycolic acid)-Polyethylene Glycol QTc Corrected QT interval RAGE Receptor for Advanced Glycation End products REST RE1-Silencing Transcription factor RGD Arginine-Glycine-Aspartic acid RhoA/ROCK Ras homolog family member A/Rho-associated protein kinase ROS Reactive Oxygen Species SCN9A Sodium Voltage-Gated Channel Alpha Subunit 9 SCS Spinal Cord Stimulation SDNN Standard Deviation of Normal to Normal intervals sFlt-1 Soluble Fms-like Tyrosine kinase 1 SGC Satellite Glial Cell (primary context

Glutathione (GSH) is a tripeptide composed of three amino acids: glutamine, glycine, and cysteine

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