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Description

Laffleur F, Millotti G, Lagast J

Proportion of delays significantly decreased from 12.7% to 4.1% between 2018 and 2024 (p 17 years, GCS6, requiring mechanical ventilation were randomized within 18 hours of symptoms to either 72 hours of TTM to moderate hypothermia (MH = 32-34C) followed by a controlled rewarming at 0.05-0.1C/hour and maintenance of normothermia (NT = 36-37C) for up to 7-days or TTM to NT (36-37C) for 7-days using endovascular/surface cooling

S.HughesJ

T., 2015

Preclinical studies document stimulation of collagen and glycosaminoglycan synthesis, upregulation of antioxidant enzymes including superoxide dismutase, and activation of matrix metalloproteinase pathways involved in tissue remodeling and scar resolution