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Glutamine Metabolism and Cancer Therapy: A Comprehensive Guide AxisPharm Glutamine metabolism pathways in cancer cells. Glutamine is transported to the cytoplasm by glutamine transporters on the cell membrane(SLC1A5,SLC38A1,& SLC6A14)& then to the mitochondria via SLC1A5 variants. In the mitochondrial matrix,glutamine is Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response ScienceDirect Glutamine Side Effects vs Glutamate: Nutrition and Safety From Krebs to clinic: glutamine metabolism to cancer therapy Nature Reviews Cancer
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