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Heavy metals such as Pb, Hg and U have harmful effects on the kidney, particularly on the proximal tubules, which suggests that the nephron plays an important role in the active transport of heavy metals [24,25]

found that Astragalus mongholicus not only reduces -synuclein aggregation in the striatum but also decreases Proteobacterias relative abundance in PD models (Wan et al., 2022), indicating Astragalus mongholicus inhibits TMAO production while reducing -syn aggregation leading to PD

doi:10.1016/j.bbrc.2008.08.129

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