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When this process is blocked in vivo , we note age-dependent TDP-43 pathology and sex-specific behavioral deficits linking TDP-43 SUMOylation with aging and disease

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(ii) L is a cleavable linker of formula -A-W-, wherein A is an optional stretcher unit linked to the Ab, and W is a cleavable moiety linked to D (iii) D is an inhibitor of topoisomerase I, e.g., exatecan

BPC-157 has substantial preclinical evidence (hundreds of published studies) and early-phase human data, but lacks the large-scale randomized controlled trials that would be required for regulatory approval

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