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doi:10.3390/biomedicines9111547 Vasireddi N, Hahamyan H, Salata MJ, et al

This requirement for specificity in method, materials, and purification conditions introduces a substantial bottleneck in the time required to carry out purifications across a large universe of differing protein types

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This phenomenon allows AA and AG to encode serine or threonine, while GA can direct the incorporation of phenylalanine or tyrosine [196]