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Haploinsufficiency of SCN1A encoding the voltage-gated sodium channel Na( V )1.1 causes Dravets syndrome, which has been proven to result in the display of autism-like behaviour

However, given that PT-141 is an as-needed medication, men typically use it infrequently, further limiting long-term exposure risks

These findings, although obtained from models of oxidative stress and mitochondrial dysfunction rather than in autism models, are highly relevant because they target biological mechanism that are also characteristic of ASD (Sachdeva et al., 2022)

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