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Notably, TGR5 agonism reduces pro-inflammatory cytokines, including IL-6, IFN-, and TNF-, while enhancing anti-inflammatory IL-10 production (126, 127), and promotes macrophage polarization toward an anti-inflammatory phenotype (126, 127) ( Figure 2 )

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Reversal of this age-associated decline using the NAD + precursor nicotinamide mononucleotide (NMN) restored functional fertility, even when treatment was started at a post-reproductive age

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