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This systemic perspective opens new pathways for PD prevention and treatment, suggesting that targeting gut microbiota, modulating splenic immunity, clearing hepatic -syn, or utilizing skin biopsies for early diagnosis may become important future therapeutic strategies

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10.3390/membranes13060542 317 TaghaviS.RamezaniM.AlibolandiM.AbnousK.TaghdisiS

The combination action of VEGF as a pro-angiogenic factor and an immunouppressor renders the TME tolerogenic, allowing tumor growth and spread

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