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Loureiro D, Tout I, Narguet S, Bed CM, Roinard M, Sleiman A, Boyer N, Pons-Kerjean N, Castelnau C, Giuly N, Tonui D, Soumelis V, El Benna J, Soussan P, Moreau R, Paradis V, Mansouri A, Asselah T

Emerging evidence suggested that NIN diminished the oxidative stress and inflammation induced by doxorubicin through reducing inflammatory molecules and replenishing reduced antioxidant armory (Wali et al., 2020)

The anti-ferroptotic potential was established by showing that OH Py 2 N 2 increases levels of glutathione peroxidase, decreases lipid peroxidation, and readily binds iron (II) and (III)

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EGCG also affected the ferroptosis pathway by reducing the expression of the key target tsRNA-13502 and changing the levels of important ferroptosis regulators (GPX4/SLC7A11 and ACSL4)