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The unrefined plant extracts and isolated compounds have demonstrated a reduction in the amount of fat in the body, as well as a manifestation of their potential through the prevention of obesity caused by diet, thus making them fit for the development of the new, safer, and more potent anti-obesity treatments.[7] The renowned phytochemical constituents which include terpenoids, flavonoids, saponin, phenol, and alkaloids consist of key biological benefits

However, although weight loss was observed in some studies, it did not occur in all studies (2)

The desired C2/3-diamino-group may be introduced via a two-step sequence involving an amination of C2-chloro- group with, for example, ammonia and reduction of C3-nitro group (via, e.g., hydrogenation) to give the precursor 16

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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Cerk IK, Salzburger B, Boeszoermenyi A, Heier C, Pillip C, Romauch M, et al