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Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models

In RPE cells, iron overload downregulates the expression of circSPECC1 and Rpe65, which disrupts RPE cells polarity, induces ultrastructural abnormalities and atrophy, and activates microglia

The simulation lasted 1500 ps and the temperature of the calculated system was set to 300 K

Growing evidence has established strong associations between gut microbiota and the pathogenesis of ADs, including SLE, rheumatoid arthritis, and multiple sclerosis [6, 7]

CS exposure depleted ELF GSH levels by 4 hours from 100 M to 25 M, which was roughly the level where it remained until the end of the CS exposure (Figure 3A)