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Fibroblasts are responsible for the deposition of extracellular matrix components such as collagen, fibrin, and elastin, and experimental modulation of their activity is commonly used to study tissue regeneration mechanisms

doi: 10.1172/JCI45014 4 FanYHeS

Clinical attention has switched to prevention in MCI cohorts or middle-aged individuals displaying early MAPT (tau) tangles and amyloid deposition since mTOR inhibition is more efficient at removing early-stage aggregates (235)

Additionally, the expression of certain microRNAs, such as miR-137 and miR-9, has been found to regulate ferroptosis in melanoma by targeting glutamate metabolism, which could have implications for therapy resistance and sensitivity

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