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Cells were then fixed in formaldehyde 4% (when the intracellular staining was performed the following day) or BD Fixation/Permeabilization solution (when the intracellular staining was performed on the same day) for 20 min at 4 C

In reaction to AD, astrocytes experience a shift in profile, one that is reactive and pro-inflammatory while losing homeostatic roles thus disrupting BBB integrity, ion and neurotransmitter buffering, and energy metabolism (Liddelow et al., 2017

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