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Cumulatively, current preclinical and clinical evidence demonstrates that mitochondria-targeted therapeutic strategies stand out as the most well-established class for PD intervention

Following this, neuroepithelial cells were dissociated 1:6 with Accutase (Gibco) and maintained for six days in NDM supplemented with CHIR99021, SB431242, DMH1, 0.5 M Purmorphamine (Stemgent), and 0.1 M retinoic acid (Sigma)

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Injury-induced shedding of extracellular vesicles depletes endothelial cells of Cav-1 (caveolin-1) and enables TGF- (transforming growth factor-)-dependent pulmonary arterial hypertension