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This leads to impaired glutamate reuptake, resulting in elevated extrasynaptic glutamate concentrations and subsequent neuronal excitotoxicity (Robinson et al., 2014a

(2013) 8:e82669

Al Krad et al., The protease inhibitor Nirmatrelvir synergizes with inhibitors of GRP78 to suppress SARS-CoV-2 replication, bioRxiv, doi:10.1101/2025.03.09.642200

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