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pmid:18155253

Notably, all compounds quantified in saliva were present in unconjugated form, presumably as a result of deconjugation by a -glucuronidase ( 6 Metabolism Dietary polyphenols and particularly procyanidins, which are highly prevalent in Pycnogenol , undergo extensive in vivo metabolism

6,18,19 Hyperbilirubinemia is likely secondary to impairment of bilirubin conjugation and clearance by the liver leading to indirect hyperbilirubinemia